Momentary reward induce changes in excitability of primary motor cortex

Abstract

Objective To investigate the human primary motor cortex (M1) excitability changes induced by momentary reward. Methods To test the changes in excitatory and inhibitory functions of M1, motor-evoked potentials (MEPs), short-interval intracortical inhibition (SICI) and short-latency afferent inhibition (SAI) were tested in the abductor pollicis brevis (APB) muscle of non-dominant hand in 14 healthy volunteers by transcranial magnetic stimulation (TMS) during a behavioral task in which subjects were pseudorandomly received either reward target or non-target stimuli in response to a cue. To control sensorimotor and attention effects, a sensorimotor control task was done replacing the reward target with non-reward target. Results The SICI was increased, and the SAI was decreased significantly during the presentation of the reward target stimuli. Those changes were not evident during non-reward target stimuli in the sensorimotor control task, indicating that this change is specific to momentary reward. Conclusions Momentary rewarding is associated with change in intracortical inhibitory circuits of M1. Significance: TMS may be a useful probe to study the reward system in health and in many diseases in which its dysfunction is suspected.