Abstract
Four new depsidones, mollicellins O–R (compounds 1–4), along with three known compounds 5–7, were isolated from cultures of the fungus Chaetomium sp. Eef-10, an endophyte isolated from Eucalyptus exserta. The structures of the new compounds were elucidated by analysis of the 1D and 2D NMR and HR-ESI-MS spectra. The known compounds were identified by comparison of their spectral data with published values. Compounds 1–7 were evaluated for antibacterial activities against Staphylococcus aureus (sensitive and resistant strains), Escherichia coli, Agrobacterium tumefaciens, Salmonella typhimurium, Pseudomonas lachrymans, Ralstonia solanacearum, Xanthomonas vesicatoria and cytotoxic activities against two human cancer cell lines (HepG2 and Hela). Mollicellin H (6) displayed best antibacterial activity, with IC50 values of 5.14 µg/mL against S. aureus ATCC29213 and 6.21 µg/mL against S. aureus N50, MRSA, respectively. Mollicellin O (1) and mollicellin I (7) also exhibited antibacterial activities against S. aureus ATCC29213 and S. aureus N50. Mollicellin G (5) was active against both two human cancer cell lines, with IC50 values of 19.64 and 13.97 µg/mL while compounds 6 and 7 only showed cytotoxic activity against one cell line. In addition, mollicellin O (1) showed antioxidant activity based on DPPH radical scavenging, with an IC50 value of 71.92 µg/mL.
Highlights
Plant endophytes are regarded as a sort of particular-biotope microorganisms that reside in the tissues of living plants without causing any immediate obvious negative effects in their host plants [1,2]
Chaetomium species have been reported to produce about depsidones, the mollicellins and the resulting extracts were partitioned into petroleum ether, ethyl acetate (EtOAc)- and we focused attentionether on Chaetomium sp.fractions
Endophytic fungi as important sources of natural active substances have been used to obtain novel bioactive secondary metabolites with potential applications in the agricultural and medical sectors, which can act as lead targets of pharmaceutical and medicinal potential [27]
Summary
Plant endophytes are regarded as a sort of particular-biotope microorganisms that reside in the tissues of living plants without causing any immediate obvious negative effects in their host plants [1,2]. Depsidones are a group of fungal metabolites that have attracted the attention of natural product chemists due to their diversified structures and potent biological activities. Chaetomium species have been reported to produce about 14 depsidones, the mollicellins A-N [24,25,26]. Details of the structure determination and biological activities of these compounds presented . Depsidones are a group of fungal metabolites that have attracted the attention of natural product chemists due to their diversified structures biological activities.(MeOH). Details of the structure determination and biological activities of by 1D and 2D NMR spectroscopy and by comparison with literature data.
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