Molecular targeted therapy of osteosarcoma and related clinical

Abstract

Osteosarcomais a highly heterogeneous bone cancer, which predominantly affects children andadolescents population. The outcome of patients with osteosarcoma has not changed in several decades. This plateau in survival rates highlights the need for a novel approach towards research. Novel precise osteosarcoma-targeting therapyis also developingand attempwith the hope ofaddressing this issue. This reviewsummarizes the current development of molecular mechanism underlying osteosarcoma, current molecular therapeutic targets against immune system, extracellular and intercellular signalingtransduction pathway of the bone metabolism, microRNA, as well as therapies that target these mechanisms with updated informationon fundamental research, preclinical study, and clinical trials. To date, even though few targeted drugs that specifically targeting osteosarcoma have been approved for clinical use, these new approaches that mentioned above and new strategies and methords for clinical trialcouldhelp us explore the full potential of targeted therapies in osteosarcoma.