Abstract
Aim: to study the relationship between homocysteine, cysteine and glutathione in blood serum and various single nucleotide polymorphisms (SNPs) of genes involved in folate metabolism in patients with proliferative breast disease and breast cancer. Material and methods . The study included 112 patients with proliferative breast lesions and breast cancer in Transbaikalia. The control group consisted of 144 women having no breast cancer. Blood levels of homocysteine, cysteine and glutathione were evaluated by HPLC (high performance liquid chromatography). Genotyping was performed by polymerase chain reaction with the detection of amplification product in real-time. Results . Molecular-genetic testing revealed no association between breast disease and genetic polymorphisms of MTHFR(C677T), MTHFR(A1298C), MTR(A2756G), MTRR(A66G) in women with proliferative breast lesions and breast cancer, however, in contrast to the control group, the concentrations of homocysteine and glutathione were increased.
Highlights
Song A., Zhao L., Li Y., Wu L., Li Y., Liu X., Lan S
Haplotypes of the MTHFR gene are associated with an increased risk of breast cancer in a Han Chinese population in Gansu province
Aim: to study the relationship between homocysteine, cysteine and glutathione in blood serum and various single nucleotide polymorphisms (SNPs) of genes involved in folate metabolism in patients with proliferative breast disease and breast cancer
Summary
Song A., Zhao L., Li Y., Wu L., Li Y., Liu X., Lan S. Haplotypes of the MTHFR gene are associated with an increased risk of breast cancer in a Han Chinese population in Gansu province. Lin J., Lee I.M., Song Y., Cook N.R., Selhub J., Manson J.E., Buring J.E., Zhang S.M. Plasma homocysteine and cysteine and risk of breast cancer in women.
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