Abstract
Objective To investigate the molecular epidemiology of Staphylococcus aureus through analyzing the antibiotic resistance and genotypes of the isolates collected from 10 main cities of China from 2010 to 2011.Methods A total of 507 consecutive and non-duplicate S.aureus isolates were collected from 12 hospitals of 10 cities in China.Antibiotic susceptibility test for 20 antibiotics and spa typing were carried out on all isolates.Results The prevalence of methicillin-resistant S.aureus (MRSA) was 52.9％ (268/507).97.4％ (261/268) of those isolates were multidrug resistance.Among all methicillin-sensitive S.aureus (MSSA) isolates,multidrug resistant rate was 26.8％ (64/239),in which spa-t796 phenotype accounted for 23.4％ (15/64).Thirty-four spa types were identified among MRSA,of which the major clones were spa-t030,spa-t037,spa-t002,spa-t570,spa-t437 and spa-t311.Fifty-eight spa types were detected among MSSA,of which spa-t701,spa-t189,spa-t796,spa-t091 and spa-t571 were the major strains.The geographical distribution of these strains varied significantly.The strains with spa-t030 phenotype was more commonly distributed in Beijing,Xi'an,Wuhan,Tianjin and Chongqing.The spa-037 and spa-t002 were the dominant strains in Shanghai,while spa-t037,spa-t311 and spa-t570 were prevalent strains in Guangzhou,Hangzhou and Shenyang respectively.Notably,the strains with vancomycin MIC greater than or equal to 1 mg/L were largely detected in spa-t037,spa-t570 and spa-t701 (P＜0.05).However,rifampicin resistance was overwhelmingly associated with spa-t030 (P＜0.001).The oxacillin MICs were relatively low in the strains of spa-t437 as compared with other clones (P＜0.001).Conclusion The spa types possessed a feature of distinctive geographical distribution.The major spa types were associated with specific antimicrobial resistance,suggesting more attention should be paid to the phenotypes of bacterial strains for the treatment purpose in clinic. Key words: Staphylococcus aureus ; spa typing; Multidrug resistance; Vancomycin
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