Abstract
ObjectiveTo determine the antimicrobial susceptibility patterns and prevalence of blaOXAtype carbapenemases among Acinetobacter baumannii (A. baumannii) isolates obtained from Iranian patients. MethodsThe isolates were identified from patients hospitalized between July 2011 and June 2013 in three hospitals in the Kermanshah region, Iran. All of the suspected colonies were assessed by using standard biochemical tests. Antimicrobial susceptibility testing was performed on all isolates by the Kirby-Bauer disk diffusion method. The main groups of OXA carbapenemase genes (blaOXA-23-like, blaOXA-24-like/40-like, blaOXA-51-like, blaOXA-58-like) were detected using PCR and finally carbapenem-resistant A. baumannii were genotyped by pulsed field gel electrophoresis. ResultsEighty four clinical isolates were collected from the hospitalized patients. These isolates were confirmed as A. baumannii. All isolates were found to carry blaOXA-51-like. blaOXA-23-like and blaOXA-24-like/40-like were seen in 56 and 24 isolates respectively and blaOXA-58-like was not detected in any of the isolates with similar in our previous study. Among 40 A. baumannii isolates that selected for pulsed field gel electrophoresis analysis, we obtained 6 pulsotypes (including 4 common types and 2 single types). ConclusionsOur study and our previous study (2010–2011) indicated that multidrug-resistant A. baumannii strains are spreading and carbapenemase resistance are common in Iran. More researcher and greater emphasis on the prevention of health care-associated transmission of multidrug-resistant Acinetobacter infection are essential.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.