Abstract
Ceramide glucosyltransferase (glucosylceramide synthase, GlcT-1, EC 2.4.1.80) catalyzes the first step in glycosphingolipid synthesis, the transfer of glucose from UDP-glucose to ceramide. The product, glucosylceramide, serves as a core structure for over 300 species of glycosphingolipids. The enzyme is a key regulatory factor controlling intracellular levels of ceramide and glycosphingolipids. We have cloned the gene for mouse ceramide glucosyltransferase,Ugcg.The gene spans approximately 32 kb and is composed of 9 exons and 8 introns. The promoter region was found to lack TATA and CAAT boxes but contains Sp1 binding sites, which are indicators of typical house-keeping genes. In addition to these general transcription factor binding sites, the motifs for AhR, NF-κB, AP-2 and GATA-1 binding sites were found.
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