Abstract
The complete genome sequence of beak and feather disease virus (BFDV) from a purple crowned lorikeet (Glossopsitta porphyrocephala) was characterized. The genome consists of 2,010 nucleotides and encodes replicase-associated protein and capsid protein. This is the first evidence of BFDV infectivity and complete genome sequence for this novel host.
Highlights
Psittacine beak and feather disease (PBFD) is a very common, chronic, and fatal viral disease of wild psittacine birds throughout the world, with all parrots, lorikeets, and cockatoos in endemic areas considered susceptible [1, 2]
beak and feather disease virus (BFDV) itself is a nonenveloped icosahedral virus with an approximately 2.0-kb circular single-stranded DNA genome that typically encodes two major proteins known as replication-associated protein (Rep) and capsid protein (Cap), with a potential stem-loop structure located between them [3, 6, 7]
Recent research reveals that despite much intralineage variation, the BFDV genomes circulating in lorikeets are genetically segregated and ancient compared to other contemporary BFDV lineages [9]
Summary
Psittacine beak and feather disease (PBFD) is a very common, chronic, and fatal viral disease of wild psittacine birds throughout the world, with all parrots, lorikeets, and cockatoos in endemic areas considered susceptible [1, 2]. The causative agent of the disease, beak and feather disease virus (BFDV), belongs to the family Circoviridae [3] and is probably the dominant pathogen of wild Psittaciformes, with strong historical evidence of PBFD occurring naturally in wild Australian birds for more than 120 years [4, 5]. BFDV itself is a nonenveloped icosahedral virus with an approximately 2.0-kb circular single-stranded DNA (ssDNA) genome that typically encodes two major proteins known as replication-associated protein (Rep) and capsid protein (Cap), with a potential stem-loop structure located between them [3, 6, 7].
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