Abstract
The purpose of this review of the 81 publications is to discuss the current national and international data on the prediction of neurological outcomes after sudden circulatory arrest (SCA) using molecular biomarkers. The review discusses the current state of the problem of neurological outcomes after a sudden circulatory arrest, the principal therapeutic measures to improve these outcomes and currently available clinical, laboratory, and instrumental methods of diagnosis and prediction of neurological outcomes after a sudden circulatory arrest.
Highlights
The survival rate after a sudden circulatory arrest (SCA) is 10—20%
The threshold values of the neuron-specific enolase (NSE) blood concentrations for predicting a neurological outcome after the SCA range from 33 ng/ml to 90.9 ng/ml over 24— 72 hours after resuscitation, according to various studies [48,49,50]
The use of artificial hypothermia in the post-resuscitation period significantly changes the dynamics of the concentration and informative value of molecular biomarkers
Summary
The survival rate after a sudden circulatory arrest (SCA) is 10—20%. According to data over the period 2011—2015, in the USA, the survival rate after all types of SCA was on average 11.4%, and in 27 European countries (2014), it was on average 10.7% [1,2]. The purpose of this review of the 81 publications is to discuss the current national and international data on the prediction of neurological outcomes after sudden circulatory arrest (SCA) using molecular biomarkers.
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