Abstract
Schizotypy constitutes a useful model for the study of schizophreniform traits in healthy individuals, as it circumnavigates many confounders found in schizophrenia-patients. To examine molecular-biological indicators of the fully-dimensional schizotypy-model, the German version of the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE) was examined regarding its associations with select relevant genetic polymorphisms. We present a number of influences of dopaminergic as well as non-dopaminergic genetic variants on sub-facets of schizotypy, whereof all can be interpreted in line with the current dopamine-hypothesis of psychosis in schizophrenia. Additionally, we examined correlations between schizotypy-dimensions and expression-levels of potentially relevant genes in the peripheral blood of healthy males. Preliminary analyses show significant correlations between the O-LIFE subscales and the expression of genes involved, i.a., in dopamine-regulation. Our findings indicate that schizotypy and schizophrenia share commonalities on the molecular-biological level. We therefore suggest the fully-dimensional schizotypy-model be further evaluated regarding its biological foundations.
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