Abstract
Parkinson’s disease (PD) is the most common movement disorder, clinically characterized by tremor, rigidity and bradykinesiâ. Neuropathological ly it is defined by nerve cell loss in the substantia nigra and the presence of Lewy bodies (LB) and Lewy neurites (LN)2–4. LB and LN are also the characteristic neuropathological features of dementia with Lewy body (DLB) a common late-life dementia that exists in a pure form or overlaps with the neuropathological characteristics of Alzheimer’s disease5–7. Unlike PD, DLB is characterised by a large numbe of LB in cortical brain areas. Ultrastructurally, LB and LN consist of abnotmal filamentous material3,4 KeywordsSubstantia NigraLewy BodyDementia With Lewy BodyA53T MutationPure Autonomic FailureThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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