Abstract
Molar Pregnancy: Genetic, Histological, Clinical Features and the Risk for Gestational Trophoblastic Neoplasia
Highlights
Molar pregnancy represents an obstetric complication of the first half of gestation in which the abnormal developmental of the placenta is characterized by excessive villous edema and the proliferation of the trophoblast [1]
Genetic and clinical aspects, Hydatidiform mole (HM) can be classified as complete (CHM) or partial (PHM) hydatidiform mole [1,2]
complete hydatidiform mole (CHM) is negative for p57 while non-molar and partial hydatiform mole (PHM) present positivity in villous stroma and cytotrophoblast cells [29]
Summary
Sue Yazaki Sun, Marcia Marcelino de Souza Ishigai, Rosana Mercante Martinez, Maria Teresa de Seixas Alves and Andréa Cristina de Moraes Malinverni2,3*. Hydatidiform mole (HM) is a complication of pregnancy, genetically abnormal, characterized by several degrees of trophoblastic proliferation and hydropic degeneration of chorionic villi with potential for malignant transformation. The HM is classified as complete hydatidiform mole (CHM) and partial hydatiform mole (PHM). The distinction between CHM and PHM and non-molar abortions (NM) is very important since the risk for the development of postmolar gestational trophoblastic neoplasia is higher in CHM. This article is a brief review of relevant topics about genetic, histological and clinical features of molar pregnancy
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