Abstract
The development of nanozymes has garnered significant attention in biosensing applications owing to their exceptional catalytic properties and structural tunability. Herein, we present a yolk-shell nanozyme derived from metal-organic frameworks (MOFs) featuring CoN/Co-NC@SiO2 architecture, exhibiting remarkable oxidase mimetic activities for colorimetric glutathione (GSH) detection. The synthesis involves a facile pyrolysis process of cobalt-based MOFs encapsulated within a silica shell, resulting in a unique yolk-shell nanostructure with CoN/Co-NC active sites. Yolk-shell CoN/Co-NC@SiO2 has been studied in detail as an oxidase and catalase-like nanozyme. In consideration of structural and composition modulation, including hydrophilic SiO2 shell, the unique cavity, a high specific surface area and dispersed active sites, the CoN/Co-NC@SiO2 was proposed for colorimetric detection of glutathione with its oxidase-like activities. Based on the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by CoN/Co-NC@SiO2, a wide linear detection range of 0.5–60 μM as well as a lower detection limit of 0.054 μM were obtained. Our research shows that optimizing structure and composition plays an important role in the construction of multiple-enzyme activity and offers bright potential applications of MOF-derived yolk-shell nanozymes in biosensing and medical diagnostics.
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