Abstract
Effects of iontophoretic application of ephedrine (an indirect adrenomimetic that evokes noradrenaline liberation) and obsidane (a blocker of β-adrenoreceptors) on extra stimulus-related modifications of evoked unit spike activity in cortical field 4 were studied in chronic experiments on cats. Neuronal responses were evoked by skin electrostimulation (SES) of extremities; a flow of air blowing on the muzzle 1.0 sec before SES was used as the extra stimulus. In most cases, the SES-evoked unit activity was depressed by ephedrine application, whereas obsidane enhanced it. Extra stimulus-related depression of the SES-evoked responses was removed by obsidane but it did not change or become even more pronounced during ephedrine applications. It is concluded that depressive effects caused by the extra stimulus on the SES-evoked responses of cortical neurons are essentially determined by noradrenergic mechanisms.
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