Abstract
Abstract not available.
Highlights
Imbalances in the mu (μ) opioid receptors (MORs) and kappa (κ) opioid receptors (KORs) systems in the skin or central nervous system are thought to contribute to the pathophysiology of severe chronic pruritus14-18
– Unlike MOR agonists, MOR antagonists and KOR agonists are not associated with addictive potential[11-13]
Imbalances in the MOR and KOR systems in the skin or central nervous system are thought to contribute to the pathophysiology of severe chronic pruritus[14-18]
Summary
Conditions such as uremic pruritus (UP) and prurigo nodularis are characterized by chronic pruritus, which negatively impacts quality of life (QoL), sleep, and mood[1-7]. Opioid receptors and their endogenous ligands are involved in the regulation of itch, with activation of mu (μ) opioid receptors (MORs) causing itchy skin and activation of kappa (κ) opioid receptors (KORs) reducing itch (Figure 1)[8-10]. – Unlike MOR agonists, MOR antagonists and KOR agonists are not associated with addictive potential[11-13]. Imbalances in the MOR and KOR systems in the skin or central nervous system are thought to contribute to the pathophysiology of severe chronic pruritus[14-18]. Targeting MORs and KORs represents an active area of research for novel treatments[14,16]. Gi/Go, Gi/Go protein; KOR, kappa (κ) opioid receptor; MOR, mu (μ) opioid receptor
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