Abstract
The influence of the κ-opioid receptor agonist, enadoline, on endogenous glutamate release was investigated in rat and marmoset striatal synaptosomes. Enadoline decreased 4-aminopyridine (2 mM)-stimulated glutamate release (rat: IC 50 ∼ 8.7 μM, marmoset: IC 50 ∼ 2.9 μM). The effect of enadoline was reversed by nor-binaltorphimine (5 μM). These data indicate that, in the striatum of the rat and marmoset, κ-opioid receptor agonists can modulate glutamate release. These findings may have implications for the treatment of Parkinson's disease.
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