Abstract
Chronic atrophic gastritis (CAG) is well-known related with multiple pathogenic factors and normally therapies comprised by western or Chinese medicines. The present study was designed to identify the bacterial community characterized by 16S rRNA amplicon sequencing and determine the modulate affection of bacterial composition response western and Chinese medicine Qinghuayin (QHY) as well as antibiotic on model rats. The result shown the overall structure alteration of bacterial appeared under medicine intervened, antibiotic caused a marked depletion in bacterial diversity and richness. The enrichments of Firmicutes (85.1–90.7%) in antibiotic-free converts into Bacteroidetes (30.7–34.6%) in antibiotic-added model rat were demonstrated. Firmicutes as the most dominant phylum in antibiotic-free treatments and significantly decreased till 21.9–68.5% in antibiotic-added treatments. Especially QHY-treated rats showed highest RA of Firmicutes (90.7%) and the amelioration of CAG using QHY attributed by beneficial bacterial enrichment, especially Ruminococcus, Lactobacillus and Bifidobacterium. In addition, alpha and beta diversity analysis also demonstrated the clear dispersion and aggregation that revealed the alteration and steady of bacterial community structures. In summary, QHY has potential application value in the treatment of CAG, which attributed to close relation with the modulatory of internal bacterial communities.
Highlights
Atrophic gastritis (AG) is chronic infection, and its primary symptoms are atrophy or/and gastric organs intestinal metaplasia
Overall structural profile from phylum to genus in microbiota composition In order to identify the profile of specific group among the gastrointestinal microbial community in case of chronic atrophic gastritis (CAG) rats after medicine and antibiotic intervention
Higher relative abundance (RA) of Firmicutes were detected in medicine intervened group and QHY has richest abundance compare with control
Summary
Atrophic gastritis (AG) is chronic infection, and its primary symptoms are atrophy or/and gastric organs intestinal metaplasia. Chronic atrophic gastritis (CAG) is a kind of the foremost common digestive system maladies in clinical practice, with assessed 50% of the world populace having the Hp contamination. These were required for compelling the medicate for chronic atrophic gastritis (CAG) with around 20% repeat rate [30]. Qinghuayin (QHY) is an important Chinese formulation, which is extensively utilized in the dealing of chronic atrophic gastritis (CAG) depend on the TCM clinical models of defrayal heat and determining dampness. A little Chinese investigation has described great effectiveness/protection of QHY in chronic atrophic gastritis (CAG) dealing. Due to chronicity and repeat of this illness, numerous sufferers have put their concentrations on elective medications such as conventional Chinese medicine [7]
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