Abstract
The study aims to obtain and characterize new composite materials with potential application as antimicrobial wound dressings releasing an anti-inflammatory biologically active substance indomethacin. The preparation of the material involves an impregnation of the cotton fabric with chitosan crosslinked with citric acid. Indomethacin interacts with the chitosan by ionic bonds at the appropriate pH. The obtained materials were characterized by infrared spectroscopy and optical microscopy. The mechanism of the indomethacin release from composite materials in phosphate buffer pH 7.4 at 37 °C was examined using different kinetics models. The concentration of citric acid affects the release of the drug, and the material with the highest concentration of citric acid has more antimicrobial activity than the other samples. The composites showed a slightly higher antimicrobial effect against Gram-negative Pseudomonas aeruginosa than against Gram-positive Bacillus cereus.
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