Abstract
BackgroundThe Lumbar sagittal parameters might be related to modic changes (MCs). However, studies on this topic have rarely been reported. The aim of this study was to identify the relationships between the lumbar sagittal parameters and the development of MCs.MethodsThe lumbar sagittal parameters of 321 patients with chronic low back pain from May 2016 to August 2018 were measured on X-ray by using Surgimap surgical planning software. Univariable analyses were used to test the potential variables of interest. Logistic regression models were then performed for the significant parameters to identify the independent factors associated with the development of MCs.ResultsMore patients in the MCs group were older with more number of female than in the disc degeneration group (p < 0.05). In the univariate analysis, significant differences were detected for the parameters of lumbar lordosis, sacral slope, intervertebral height index, endplate concave angle, and intervertebral angle only at the L5/S1 level between the two groups. The results of logistic regression analysis showed that a smaller intervertebral height index was positively associated with the development of MCs at the level of L3/4 (p < 0.05). However, the positive role of gender was only for MCs at the L5/S1 level (p < 0.05).ConclusionsThe results of this study revealed that there were negative relationships between the lumbar sagittal parameters and MCs. Furthermore, being female and having a narrow intervertebral space were the independent risk factors for the development of MCs at the corresponding lumbar levels. Interestingly, body mass index might be not associated with MCs for the Chinese population.
Highlights
The Lumbar sagittal parameters might be related to modic changes (MCs)
No significant differences were found in the body mass index (BMI), white blood cell count (WBC), and the C-reactive protein (CRP) level between the two groups (p > 0.05)
In conclusion, disc degeneration (DD) and lumbar level should be considered in evaluating the relationships between lumbar sagittal parameters and the development of MCs
Summary
The Lumbar sagittal parameters might be related to modic changes (MCs). Studies on this topic have rarely been reported. The aim of this study was to identify the relationships between the lumbar sagittal parameters and the development of MCs. Vertebral endplate subchondral bone signal changes, known as modic changes (MCs), are detected clearly on magnetic resonance imaging (MRI). Several studies have shown that spinal instability plays an important role in the occurrence of pain [9, 10]. Previous studies have suggested that sagittal balance status, as an independent predictor, affects the clinical symptoms of many spinal diseases, and plays a positive role in the prognosis of patients who underwent appropriate treatment [12, 13]. Studies of sagittal parameters in MCs of the cervical spine showed that the T1 slope [14] and the C2–C7 Cobb angle [15] are potential risk factors for the development of MCs
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