Abstract
Purpose of the study The TAIL study determined plasma concentrations of lopinavir/ritonavir (LPV/RTV) over 72 hours following cessation of LPV/RTV (400/100 mg twice daily) in healthy volunteers. There was a rapid decline in LPV concentrations as RTV diminished over time [1]. Here we have determined a model to quantify the changes in LPV apparent oral clearance (CL/F) in relation to RTV concentrations.
Highlights
A one-compartment first-order absorption model was used for LPV in the combined model; under-prediction of concentrations in the early absorption phase and over-prediction in parts of the elimination phase occurred
Larger changes in LPV CL/F were observed from approximately 10 hours post-dose com
Given the complexity of the LPV-RTV interaction, potentially more complex models should be explored
Summary
Modelling the change in lopinavir apparent oral clearance over time following cessation of lopinavir/ritonavir: data from the TAIL study. Address: 1NIHR National Biomedical Research Centre, Royal Liverpool & Broadgreen University Hospital Trust, Liverpool, UK, 2St Stephen's Centre, Chelsea & Westminster Foundation Trust, London, UK, 3Department of Pharmacology & Therapeuticsm University of Liverpool, Liverpool, UK and 4School of Pharmacy & Pharmaceutical Sciences, University of Manchester, Manchester, UK. Published: 10 November 2008 Journal of the International AIDS Society 2008, 11(Suppl 1):P241 doi:10.1186/1758-2652-11-S1-P241. Abstracts of the Ninth International Congress on Drug Therapy in HIV Infection Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1758-2652-11-S1-info.pdf
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