Abstract
Objective To investigate the association between delivery mode and necrotizing enterocolitis (NEC) in very preterm (24–31 weeks’ gestational age (GA)) very-low-birth-weight (VLBW) (≤1500 g) infants. Design Population-based observational study using univariate and multivariable logistic regression analyses. Setting The Israel National VLBW infant database 1995–2015. Patients 20,223 VLBW infants, 11,832 singletons and 8391 multiples. Main outcome measures The association of NEC occurrence to delivery by cesarean section (CS) in singletons and multiples VLBW very preterm infants. Results NEC occurred in 7.6% of singletons and 6.4% of multiples. 71.5% were delivered by CS (64.7% of singletons, 80.9% of multiples). CS delivery was not significantly associated with NEC stages 2–3 in singletons; but multiple births CS were associated with significantly higher odds for NEC (OR 1.31, 95% CI 1.01–1.69). Odds for NEC were greater with lower GA, small for GA (SGA) and patent ductus arteriosus (PDA) in both singletons and multiples, and lower in multiples with antenatal corticosteroids. Conclusions We demonstrated association between deliveries by CS and increased risk for NEC only in multiple pregnancies.
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