Abstract
Abstract In isolated perfused rat liver, phenethylbiguanide inhibits the rate of glucose production from both lactate and dihydroxyacetone, but not from xylitol. With all substrates studied, phenethylbiguanide decreases the steady state concentrations of fructose 6-phosphate and α-ketoglutarate, decreases the ATP:ADP ratio, decreases citric acid cycle activity, and causes both the mitochondrial and cytosolic oxidation-reduction states to be more reduced. The results presented and discussed are interpreted to indicate that phenethylbiguanide influences hepatic gluconeogenesis by an indirect mechanism.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
