Abstract
Modafinil did not affect spontaneous and K +-evoked [ 3H]5-HT efflux from cortical synaptosomes while it increased K +-evoked tritium efflux from cortical slices, an action that became stronger in the presence of paroxetine. In contrast, dl-fenfluramine and fluoxetine were able to enhance spontaneous and/or K +-evoked tritium efflux from synaptosomes and slices. These results suggest that modafinil does not affect 5-HT transmission from cortical synaptosomes and that its 5-HT releasing action is different from that of dl-fenfluramine and fluoxetine.
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