Abstract
Acute myocardial infarction and the following ischemic heart disease remain a major cause of mortality and morbidity in the western world. Despite the advances in pharmacological and reperfusion therapies, replacing the infarcted myocardial tissue remain illusive to scientist and clinicians alike. Adult bone marrow harbors a multitude of hematopoietic and non-hematopoietic stem cells including a small subset of primitive cells such as very small embryonic like stem cells (VSELs) that carry a number of features resembling embryonic stem cells. Myocardial ischemia initiates multiple innate mechanisms that culminate in the mobilization of bone marrow-derived cells including differentiated lineage as well as undifferentiated stem cells. While the numbers of stem cells carrying pluripotent features among the mobilized stem cells is small, their differentiation and regeneration capacity appear immense. Future therapies aiming at selective mobilization of the pluripotent and primitive subsets of bone marrow-derived cells during myocardial ischemia are needed.KeywordsAcute Myocardial InfarctionMyocardial RegenerationKinase Insert Domain ReceptorChronic Ischemic Heart DiseaseAcute Myocardial InjuryThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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