Abstract
Abstract not available
 Bangladesh Journal of Medical Science Vol.19(1) 2020 p.5-10
Highlights
Colistin (Polymyxin E) is a novel antibiotic which gains importance in recent years though it was discovered a long time ago in 1947 from a bacteria Paenibacillus polymyxa var. colistinus.[1-4]
Alarming news is extensive use of colistin to treat the sturdy bacterial infections especially in ICU setting has led to development of gram-negative colistinresistant microorganism; such as colistin-resistant Enterobacteriaceae, colistin-resistant Acinetobacter baumannii (CoRAB), Pseudomonas etc. 16-19 Colistin resistance was thought due to chromosomal mutations caused by modifications of Lipopolysaccharide (LPS) at outer cell wall of gram-negative pathogens
It was believed that colistin was one of the last drugs where resistance was not spread from cell to cell. 21, 23, 24 A plasmid-borne transmissible mobile colistin-resistant gene was identified among gram-negative pathogens Escherichia coli SHP45 in Chinese pork meat in 2015
Summary
Colistin (Polymyxin E) is a novel antibiotic which gains importance in recent years though it was discovered a long time ago in 1947 from a bacteria Paenibacillus polymyxa var. colistinus.[1-4]. 16-19 Colistin resistance was thought due to chromosomal mutations caused by modifications of Lipopolysaccharide (LPS) at outer cell wall of gram-negative pathogens.
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