MO740: Decrease Serum IgG anti-oxLDL Antibodies Levels are Associated with Peripheral Arterial Disease IN PATIENTS WITH PERITONEAL DIALYSIS

Abstract

Abstract BACKGROUND AND AIMS Antibodies to oxidized LDL (anti-oxLDL antibodies) were found to indicate protection from coronary artery disease and possibly major adverse cardiovascular and cerebral events. Peripheral arterial disease (PAD), defined by a low ankle-brachial index (ABI), is associated with increased mortality in patients on peritoneal dialysis (PD). The present study aimed to determine the relationship between serum IgG anti-oxLDL antibodies level and PAD in PD patients. METHOD The present cross-sectional, a single-center study included 90 PD patients. Serum IgG anti-oxLDL antibody levels were determined by available enzyme-linked immunosorbent assays. ABI values were measured using an automated oscillometric device. Patients with ABIs of < 0.9 were categorized into the low ABI group. RESULTS In the study cohort, 23 of the 90 patients (25.6%) had low ABIs. The rates of diabetes mellitus (P = 0.010), older age (P = 0.006) as well as the serum levels of fasting glucose (P < 0.001), triglyceride (P = 0.008) and C-reactive protein (P < 0.001) were higher, while IgG anti-oxLDL antibodies (p < 0.001) were lower in the low ABI group compared with the normal ABI group. The multivariable logistic regression analysis revealed that serum levels of IgG anti-oxLDL antibodies [odds ratio (OR) 0.978, 95% confidence interval (95% CI) 0.958–1.000; P = .046) and C-reactive protein (each 0.1 mg/dL increase, OR 1.662, 95% CI 1.151–2.398; P = 0.007) were independently associated with PAD in PD patients. The area under the curve plotted to estimate the optimal level of IgG anti-oxLDL antibodies predicting PAD in PD patients by the receiver-operating characteristic curve analysis was 0.687 (95% CI 0.580–0.780; P = 0.0022). CONCLUSION Lower serum IgG anti-oxLDL antibodies together with higher C-reactive protein were associated with PAD in PD patients.