Abstract
Adenocarcinoma of the stomach is the second leading cause of cancer related death in the world. Gastric intestinal metaplasia (GIM) is an important intermediate stage in the gastric cancer cascade through a series of well-defined precursor lesions including nonatrophic gastritis, multifocal atrophic gastritis, intestinal metaplasia, and dysplasia. The prevalence of GIM is unclear in many parts of the world and few studies have evaluated the rate of progression to gastric cancer in patients with GIM. There is a lack of clarity in published guidelines regarding appropriate surveillance of patients with GIM and there is wide disparity in the management of this premalignant condition.
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