Mixed infections with Coxsackie and Lansing poliomyelitis viruses in mice.

Abstract

SummaryThe following reciprocal effects have been observed in mice infected with viruses which do not possess the same degree of pathogenicity for the host. 1. The Ohio-R strain of C virus influenced significantly both the course and outcome of experimental Lansing poliomyelitis infections in 4-week-old white Swiss mice. 2. In the presence of the Lansing infection the virulence of the Ohio-R virus seemed to be enhanced for these otherwise insusceptible animals. 3. The Nancy strain of C virus had a noticeable effect on the pathogenesis of the Lansing infection in 4-week-old mice. The frequency with which the forelimbs became paralyzed first as compared with the first appearance of hindlimb paralysis was influenced by the presence of Nancy virus in the higher levels of the CNS. The presence of Nancy virus in the lumbar region of the spinal cord, following intraspinal inoculation, seemed to limit extension of the Lansing virus thus altering the normal progress of this experimental infection. 4. There was no ...