Abstract

Mixed exposure to arsenic (As), manganese (Mn), and lead (Pb) occur frequently in the general population; however, there are few studies on the neurotoxic effects, including those on dopaminergic neurotransmission in the striatum. This study investigated tyrosine hydroxylase (TH), dopamine transporter (DAT), and vesicular monoamine transporter 2 (VMAT2) expression in the mouse striatum after exposure to As, Mn, and Pb. Mixed exposure to these metals through drinking water for 4 weeks resulted in

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