Abstract
THE PRINCIPAL factor that induces mitotic activity in the hypophysis of II sexually mature female rats is directly or indirectly related to the estrous cycle since alarge number of mitoses are found only in the postovulatory phase of the cycle (Hunt, 1942). At this phase, however, there is a considerable individual variation indicating that other factors also influence the number of mitoses. The purpose of this paper is to consider some of these secondary factors. Among these, the age of the animal is perhaps the most important and there was some indication of this in the first series of glands examinedbut in order to obtain more complete data on mitotic activity in the hypophysis in different age groups an additional series of animals was studied. The occurrence of a diurnal rhythm of mitotic activity in organs such as the kidney, submaxillary gland and epidermis has been stressed by others (Blumenfeld, 1938, 1942; Carleton, 1934).
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