Abstract
It can be caused by chronic hyperinsulinemia, inflammation, and long-term use of corticosteroids. In vivo and in vitro models have revealed that this process is secondary to the excessive production of mitochondrial oxidants, a product of mitochondrial dysfunction, even in cases where mitochondrial respiration is conserved
Highlights
Ivan Lozada Martinez1*, Daniela Torres Llinás2, Jaine Anaya Rivera2, Jennifer Jiménez Valverde2 and Milena Castro Berrio2
Insulin resistance is a condition derived from the disorder in the use of substrates for metabolic activities [1]
Insulin increases the number of type 4 glucose transporters (GLUT4) on the cell surface, via the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signaling pathway, producing the appropriate intra-cellular glucose transport for use [3]
Summary
Ivan Lozada Martinez1*, Daniela Torres Llinás2, Jaine Anaya Rivera2, Jennifer Jiménez Valverde2 and Milena Castro Berrio2. Mitochondrial Dysfunction and Insulin Resistance: Topic of High Interest in Research
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