Abstract
Psoriasis is a chronic immune-mediated skin disease, whose hallmarks include keratinocyte hyperproliferation and CD4+ T cell subsets imbalance. Dysregulated microRNAs (miRNAs) identified in psoriasis have been shown to affect keratinocyte and T cell functions, with studies on the molecular mechanisms and intrinsic relationships of the miRNAs on the way. Here, we focus on the dysregulated miRNAs that contribute to the two hallmarks of psoriasis with the miRNA target genes confirmed. We review a network, in which, upregulated miR-31/miR-203/miR-155/miR-21 and downregulated miR-99a/miR-125b facilitate the excessive proliferation and abnormal differentiation of psoriatic keratinocytes; upregulated miR-210 and downregulated miR-138 work in concert to distort CD4+ T cell subsets balance in psoriasis. The miRNAs exert their functions through regulating key psoriasis-associated transcription factors including NF-κB and STAT3. Whether flowing up or down, these miRNAs collaborate to promote the development and maintenance of psoriasis.
Highlights
Yang Xiuli and Wang Honglin*Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Translational Medicine Center, Shanghai Institute of Immunology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Psoriasis is a chronic immune-mediated skin disease driven by the coordination of genetic susceptibility, environmental triggers, and dysfunctional immune system, which is featured by the abnormal interplay between keratinocytes and T cells
Other miRNAs are likely to be added into this network with confirmed mRNA targets and established biological functions in the future
Summary
Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Translational Medicine Center, Shanghai Institute of Immunology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Reviewed by: Erle Dang, Fourth Military Medical University, China Xiang Chen, Central South University, China. Specialty section: This article was submitted to Dermatology, a section of the journal
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