Abstract
Thyroid cancer (TC) is the most common endocrine malignancy, with an incidence continuing to grow every year. Although thyroid cancer as a whole is generally indolent and relatively easy to treat, some subtypes carry a higher rate of metastasis and cancer-related mortality. A growing number of studies have focused on the dysregulation of miRNAs in TC. However, differences in methods make comparison of gene profiling data difficult. A meta-analysis of published studies comparing miRNA expression data of invasive thyroid carcinoma with paired non-invasive tumors or normal tissues was performed by searching the literature for “invasion”, “thyroid cancer”, and “miRNA”. This revealed 29 dysregulated miRNAs associated with TC in 16 articles; the presence of invasion was confirmed in each respective article by laboratory research or patient follow-up. Among these miRNAs, miRNA-146b, miRNA-221, and miRNA-222 were analyzed further due to their higher frequencies across multiple studies. Of these studies, 6 were included in the meta-analysis, as they compared invasive PTC with paired normal tissues or non-invasive PTC.
Highlights
Thyroid carcinoma (TC) is the most common endocrine malignancy, the incidence was increasing year by year
We initially collected 106 studies using the described strategy. 84 articles were excluded because they were not relevant to the aim of our study. 29 miRNAs in 16 articles were subsequently identified [7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23], with the function of dysregulated miRNAs confirmed through patient follow-up or other laboratory experiments
We explored the relationship between dysregulated miRNAs and invasion ability
Summary
Thyroid carcinoma (TC) is the most common endocrine malignancy, the incidence was increasing year by year. The overall survival rate of patients with papillary thyroid carcinoma is high [1], increased cancer recurrence and cancer-related mortality are noted in a portion of patients with papillary thyroid carcinoma [2]. Distinguishing these tumors from classic tumors has become a hot topic of research in recent years. Dysregulation of miRNA expression is a common feature in many types of human cancers, including thyroid cancer [5 6]
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