Abstract
Introduction: Recent evidence suggests disparate expression patterns of genes involved in colorectal cancer (CRC) tumorogenesis, cell-cycle regulation, and differentiation may be regulated in part by microRNAs (miRs). MiR-145a functions as a cell-cycle regulator, via TP-53 and its expression has been recently reported to be decreased in several primary cancers. This study evaluates relative expression patterns of miR-145a not only in primary CRC, but cancer-positive lymph nodes (LNs) and distant metastatic CRC tissues.
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