Abstract
Miescher’s cheilitis is an inflammatory disorder characterized by chronic lip swelling due to granulomatous inflammation. It is rare disorder first described by Miescher in 1945. It is monosymptomatic form of Melkersson-Rosenthal syndrome. We report a case of Miescher’s cheilitis in a 59-year old lady presented with recurrent swelling and erythema of upper lip and submental area with no features of facial palsy and fissuring of tongue. Laboratory tests including serum complement C3, C4 and C1 esterase inhibitor functional were within normal limits. The biopsy from the upper lip revealed dermal edema, dilated lymphatic channels and multiple granulomas. After exclusion of other causes of orofacial granulomatosis, the diagnosis of Miescher’s cheilitis was made. Patient was treated with oral hydroxychloroquine and topical tacrolimus and mometasone cream with gradual improvement.
Highlights
Miescher’s cheilitis (MC) is a rare condition, known as cheilitis granulomatosa (CG), characterized by recurrent lip swelling. This inflammatory disorder was first described by Miescher in 1945.1,2 It is monosymptomatic form of Melkersson-Rosenthal syndrome (MRS), which is characterized by edema of the lips, facial palsy and fissuring of the tongue
MC is a granulomatous inflammatory disorder and an entity included under the umbrella of orofacial granulomatosis (OFG), which was coined by Wiesenfeld in 1985.3 Here, we report a case of Miescher’s cheilitis due to its rarity
Miescher’s cheilitis is a rare disease with unknown etiopathogenesis and the swelling of lip due to granulomatous inflammation. It is a monosymptomatic form of MelkerssonRosenthal syndrome, which is characterized by the triad of orofacial edema, facial palsy and fissured tongue
Summary
Miescher’s cheilitis is an inflammatory disorder characterized by chronic lip swelling due to granulomatous inflammation. It is rare disorder first described by Miescher in 1945. It is monosymptomatic form of Melkersson-Rosenthal syndrome. We report a case of Miescher’s cheilitis in a 59-year old lady presented with recurrent swelling and erythema of upper lip and submental area with no features of facial palsy and fissuring of tongue. The biopsy from the upper lip revealed dermal edema, dilated lymphatic channels and multiple granulomas. After exclusion of other causes of orofacial granulomatosis, the diagnosis of Miescher’s cheilitis was made. Miescher’s cheilitis: A case report with literature review.
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