Abstract
The management of mid/distal esophageal and gastroesophageal junction (GEJ) cancer is challenging with only one-third patient presenting with a potentially resectable disease at diagnosis. Surgery alone treatments result in disappointing outcomes, and its utility as monotherapy has been challenged. Combined modality approach with the incorporation of neoadjuvant chemoradiation is the current standard of care for resectable patients, while definitive chemoradiation is used for locally advanced disease. The radiation techniques have evolved tremendously over past decade with the development of modern radiotherapy delivery techniques capable of safely delivering intensified treatment. This chapter provides a practical guide for evidence and treatment planning for radiation treatment strategies in the context of multimodality setting. The natural history and management of mid/lower esophageal cancer are not very different from GEJ (Siewert type I and II) cancers, and therefore, will be discussed together in this chapter.
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