Abstract
BackgroundPyrroles are widely distributed in nature and important biologically active molecules. The reaction of amines with 2,5-dimethoxytetrahydrofuran is a promising pathway for the synthesis of pharmacologically active pyrroles under microwave irradiation.ResultsMicrowave-induced polystyrenesulfonate-catalyzed synthesis of pyrroles from amines and 2,5-diemthoxytetrahydrofuran has been accomplished with excellent yield. This method produces pyrroles with polyaromatic amines.ConclusionThe present procedure for the synthesis of N-aromatic substituted pyrroles will find useful application in the area of pharmacologically active molecules.
Highlights
Pyrroles are widely distributed in nature and important biologically active molecules
We report a simple microwaveassisted method for the synthesis of N-arylpyrroles using an aqueous solution of polystyrene sulfonate
We have identified that this method works well under microwave-induced reaction conditions
Summary
Pyrroles are widely distributed in nature and important biologically active molecules. A number of publications have appeared on this reaction, but still, this method is under active investigation because of its simplicity. A number of methods and catalysts have been reported, e.g., supercritical carbon dioxide [7], silver-salts promoted three component reaction [8], manganese(III)-catalyzed [3 + 2] annulation Many of these reported methods involve the use of expensive reagents, hazardous solvents, longer reaction times and tedious workup procedure.
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