Abstract
Chalcone derivatives were synthesized by reaction of some benzaldehyde derivatives with acetophenone, then the products obtained were allowed to react with urea, thiourea and hydroxylamine, to give the heterocyclic derivatives of oxazine, thiazine and isoxazole, respectively.In this study, a series of chalcones and substituted pyrazole compounds were synthesized according to green chemistry methods of conventional and microwave irradiation by using substituted acetophenone, substituted benzaldehyde, hydrazine hydrate and PEG-400. The synthesized compounds were characterized by UV-Visible, FT-IR and 1H NMR spectral techniques. The purity of the synthesized compounds were monitored by TLC and tested for their antibacterial activity by Minimum Inhibitory Concentration (MIC) method against two different microorganisms Staphylococcus auras (MTCC3381), and Escherichia coli (MTCC739).
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