Abstract
ABSTRACTAn efficient and reproducible microwave-assisted synthesis of dialkyl ω-azidoalkylphosphonates via nucleophilic substitution of the appropriate dialkyl ω-bromoalkylphosphonates by sodium azide in water or dimethylformamide (DMF) as solvent has been developed. This process has been optimized for batch reactors. The target, structurally diverse dialkyl ω-azidoalkylphosphonates with different steric hindrance around the phosphonato groups and containing unbranched side carbon chains of different lengths (n = 2–6), has been obtained in moderate to high yields (39–87%).
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