Abstract
Microtubules are intracellular filamentous structures that comprise the cytoskeleton of all eukaryotic cells. They play a critical role in various cellular processes such as mitosis and have become an essential target for the chemotherapeutic approach to a wide spectrum of malignancies. It is thus crucial to understand the basic biology of the microtubule and be familiar with the various microtubule targeting agents used clinically. This chapter provides an overview of microtubule physiology and the novel microtubule-targeting chemotherapeutic agents that are currently being evaluated for the treatment of taxane-refractory, castration-resistant prostate cancer.
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