Abstract
By this work, molecular modeling has been used to interpret the dynamic instabilities of these macromolecules in their structures. By this investigation, multi-dimension structures of microtubules are fixed in both length and width. Via Monte Carlo simulation, the tubulins have been added from the first side of the tubule towards the opposite side by gradually growing a random position. This method is theoretically accomplished via generating a uniform random number between (0, 1) based on the Monte Carlo approach. Our calculations have been done by proper dimension around 5×10-6 meters of length that consists of 2000 tubulin dimers. The structure growth rates are based on soluble tubulin dimer concentration. Hereby all results were run between 6-12 times in our modeling of any conditions. There have been recorded value numbers, average length, free tubulin concentration, and the important data of thermodynamic parameters for each simulation.
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