Abstract
Alterations in the expression of microRNA (miR)-138 have been demonstrated to result in the development of several malignant tumours. However, the possible function of miR-138 in human glioma cells remains unclear. The present study demonstrated that miR-138 was significantly downregulated in 48 human glioma specimens by quantitative PCR analysis. The upregulation of miR-138 exerted significant antiproliferative and anti-invasive effects on glioma cells and promoted their apoptosis. In addition, cAMP response element-binding protein 1 (CREB1) was confirmed as a direct target gene of miR-138 by luciferase gene reporter assay, and the antitumour effect of miR-138 on glioma cells was significantly reversed by CREB1 overexpression. Moreover, the molecular mechanisms underlying the tumour-suppressive role of miR-138 in malignant glioma may be associated with the dephosphorylation of AKT/mTOR caused by the miR-138 upregulation-induced decrease in CREB1 expression in glioma cells. The results of the present study indicated that miR-138 may affect CREB1/AKT/mTOR signalling to regulate the proliferation, apoptosis and invasion of glioma cells and the malignant progression of glioma, thereby suggesting that miR-138 may be a potential target for the treatment of gliomas.
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