Abstract
This chapter discusses examples regarding specific localization, interaction, and response to some physiological manipulations of brain serotonin and catecholamines. Catecholamines have long been implicated in the central regulation of the stress reaction and in some forms of hypertension. The specific localization of catecholamines in selected brain stem areas that formed a part of recognized circuits for the central cardiovascular control, prompted to study the changes in steady state level of catecholamines in those areas after acute immobilization stress and in spontaneous hypertensive (SH) rats. as the reason that catecholamine metabolism, and changes in the peripheral sympathetic system also occur in hypertension, it is tempting to speculate that central catecholaminergic areas could control the catecholamine metabolism in the periphery, or that central catecholamines are able to respond to corresponding changes in peripheral amines. Serotonin is also concentrated in those brain areas, and this amine has been implicated in the central control of hypertension as well as in the central regulation of the stress reaction.
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