Abstract
Inertial Microfluidics offer a high throughput, label-free, easy to design, and cost-effective solutions, and are a promising technique based on hydrodynamic forces (passive techniques) instead of external ones, which can be employed in the lab-on-a-chip and micro-total-analysis-systems for the focusing, manipulation, and separation of microparticles in chemical and biomedical applications. The current study focuses on the focusing behavior of the microparticles in an asymmetric curvilinear microchannel with curvature angle of 280°. For this purpose, the focusing behavior of the microparticles with three different diameters, representing cells with different sizes in the microchannel, was experimentally studied at flow rates from 400 to 2700 µL/min. In this regard, the width and position of the focusing band are carefully recorded for all of the particles in all of the flow rates. Moreover, the distance between the binary combinations of the microparticles is reported for each flow rate, along with the Reynolds number corresponding to the largest distances. Furthermore, the results of this study are compared with those of the microchannel with the same curvature angle but having a symmetric geometry. The microchannel proposed in this study can be used or further modified for cell separation applications.
Highlights
The rapid advances in Microfluidics and Nanofluidics fields have led to compact microfluidic devices and emerging cell applications that offer potential benefits in providing lab-on-a-chip (LOC) platforms for disease diagnosis and treatment [1,2,3,4,5,6,7]
One of the distinct advantages of the microfluidic systems is their capability to be integrated into other systems
The Reynolds numbers reported in this study were calculated at the beginning of the inlet, where the microchannel has uniform width of 350 μm
Summary
The rapid advances in Microfluidics and Nanofluidics fields have led to compact microfluidic devices and emerging cell applications that offer potential benefits in providing lab-on-a-chip (LOC) platforms for disease diagnosis and treatment [1,2,3,4,5,6,7]. The micro-total-analysis systems (μTAS) were designed by combining different applications/components, such as cytometers, bioreactors, and the separation into a single system [12]. Such an integrated system covering a small area requires very low amounts of fluids from microliter (10−6 L) down to attoliter (10−18 L), depending on the application and scale during its operation [8,10,11,12,13]
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