Abstract
The aim of this study was to prepare micronized taxifolin powder using the supercritical antisolvent precipitation process to improve the dissolution rate of taxifolin. Ethanol was used as solvent and carbon dioxide was used as an antisolvent. The effects of process parameters, such as temperature (35–65 °C), pressure (10–25 MPa), solution flow rate (3–6 mL/min) and concentration of the liquid solution (5–20 mg/mL) on the precipitate crystals were investigated. With a lower temperature, a stronger pressure and a lower concentration of the liquid solution, the size of crystals decreased. The precipitation temperature, pressure and concentration of taxifolin solution had a significant effect. However, the solution flow rate had a negligible effect. It was concluded that the physicochemical properties and dissolution rate of crystalline taxifolin could be improved by physical modification such as particle size reduction using the supercritical antisolvent (SAS) process. Further, the SAS process was a powerful methodology for improving the physicochemical properties and radical scavenging activity of taxifolin.
Highlights
Taxifolin, 3,3’,4’,5,7-pentahydroxiflavanon, is an active compound isolated from the xylem ofLarix gmelinii [1,2]
Taxifolin has a positive effect on human health, as it prevents accumulation of free radicals [3,4], influences the physical properties of lipids in biological membranes [5], ameliorates cerebral ischemia-reperfusion injury [6] and activates the formation of collagen fibers [7]
Taxifolin is a natural compound with poor solubility, which leads to a low bioavailability [8]
Summary
3,3’,4’,5,7-pentahydroxiflavanon, is an active compound isolated from the xylem ofLarix gmelinii [1,2]. 3,3’,4’,5,7-pentahydroxiflavanon, is an active compound isolated from the xylem of. Taxifolin can be used as a natural antioxidant additive in the food industry [1]. The poor solubility of active pharmaceutical ingredients in water and their low dissolution rate often leads to insufficient bioavailability, which is one of the most difficult and non-solved problems in pharmaceutical technology. Taxifolin is a natural compound with poor solubility, which leads to a low bioavailability [8]. This drawback limits the medical development as well as the use of food, health products and cosmetics
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