Abstract
We demonstrate surface acoustic wave (SAW) induced microparticle manipulation in a microstructured disposable glass-polymer composite superstrate, positioned on a piezoelectric substrate with a single, slanted SAW transducer. An excited SAW was coupled from the piezoelectric substrate into the superstrate, which acted as a transversal resonator structure. We show that the energy transmitted into the superstrate allowed acoustophoretic particle manipulation, while the wide frequency response of the SAW transducer enabled tuneable pressure distributions confined by the microchannel layout. The configuration provides a significant tolerance in positioning - making assembly easy.
Highlights
Microfluidics has enabled a number of new approaches for the manipulation of microscopic biological particles within microchannels
We show that the energy transmitted into the superstrate allowed acoustophoretic particle manipulation, while the wide frequency response of the surface acoustic wave (SAW) transducer enabled tuneable pressure distributions confined by the microchannel layout
This contrasts with conventional SAW based particle actuation in PDMS channels which require bonding and careful alignment relative to two SAW transducers
Summary
Microfluidics has enabled a number of new approaches for the manipulation of microscopic biological particles within microchannels. Each of these exploit different forces offering advantages and limitations that make them suitable for different applications (and different particles of interest, be they macromolecules or cells in suspension). Acoustic tweezing is suited to the non-contact handling of microparticles within a microchannel[1,2,3,4,5] and can be most readily implemented by attracting particles to acoustic nodes of a standing wave set up within the channel.[6,7] This provides 1D to 3D control over the position of the particles depending on the transducer system and microchannel arrangements.[8,9,10] As the pressure gradients generated by the acoustic fields extend throughout the channel, control of the pressure gradients can lead to precise particle manipulation. The magnitude of the forces acting on any particle within a fluid will be governed by the particle's acoustic contrast which, in turn, is a function of the particle's and the fluid's density and compressibility.[11]
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