Abstract
Microenvironmental Stress as the Driver of Cell Plasticity and Tumour Autonomy
Highlights
Models of cancer postulated that somatic mutations in cancer cells were responsible for cancer cell progression Fearon, et al [1]
We know that such genetic changes in the tumor cells cannot on their own account for the rapid tumour progression from local invasion to metastasis seen in cancer Taddei, et al [2]
While there is a huge body of literature focused on understanding the genetic and epigenetic changes that enable and drive cancer progression, existing models are highly diverse and focused on individual pieces of the puzzle
Summary
Dan V Nicolau1,2 and Sunil R Lakhani3 1School of Mathematical Sciences, Queensland University of Technology, Australia. 2Nuffield Department of Experimental Medicine, University of Oxford, Australia 3University of Queensland Centre for Clinical Research and Pathology Queensland, Royal Brisbane Women’s Hospital, Australia.
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