Abstract
1. 1. To define the nephron sites where changes in Na-K-ATPase activity occur during physiologic adaptations we developed a simple micromethod sensitive enough to determine ATPase activity in single segments of the mammalian nephron. 2. 2. In mice chronically loaded with potassium, Na-K-ATPase activity increased by 200% in the cortical and medullary collecting tubule, without being substantially altered in any other segment of the nephron. 3. 3. This observation suggests that the collecting tubule is the major site of renal potassium adaptation in this species.
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