Abstract
The biological effect of CdTe quantum dots (QDs) on Halobacterium halobium R1 (H. halobiumR1) growth was analyzed by a microcalorimetric technique. By using a TAM air eight channelsmicrocalorimeter, the thermogenic curves of H. halobium R1 growth were obtained at37 °C. To analyze the results, the maximum heat power(Pm) and the growthrate constants (k) were determined, which showed that they were correlated to the concentrationof QDs. The addition of quantum dots caused a gradual increase ofPm andk at lowconcentrations of QDs, and a conspicuous decrease at high concentrations. For confirmation, the turbidity(OD600) and respiratory rate at different concentrations of QDs were studied. The morphology ofH. halobium R1 cells both in the absence and presence of QDs was examinedby transmission electron microscopy (TEM). The results of these studies werecorroborated with ones derived from microcalorimetry. In this work, the mechanism ofcytotoxicity of QDs was explored through fluorescence spectroscopy, inductively coupledplasma mass spectrometry (ICP-MS) and microcalorimetry. It was clear thatmetabolic mechanism of H. halobium R1 growth was changed by the addition of QDs.To the best of our knowledge, the thermokinetics and toxicology of CdTe QDsagainst H. halobium R1 were obtained for the first time by microcalorimetry.
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