Abstract
The minimum inhibitory concentration of p -chloro- m -xylenol (PCMX) was established against Bacillus subtilis, Pseudomonas aeruginosa , and Aspergillus niger , using a serial dilution and a pour plate procedure. The inoculum size was standardized by absorbance of light at 450 mμ wavelength. The drug was subsequently complexed with methylcellulose, polyethylene glycol 6000, and polysorbate 80. A minimum inhibitory concentration for the drug against each of the microorganisms was established in the presence of varying concentrations of the macromolecules. The results demonstrated that in most cases the antimicrobial activity of PCMX was reduced in the presence of the macromolecules studied. Since it had been previously established that PCMX interacted with these molecules, it was concluded that the reduction in biological activity was a direct result of the molecular interaction.
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